Radiation induced abscopal antitumor effect

Radiation therapy is a cancer treatment that causes direct death of cells, however there number reports on anticancer effect radiotherapy, may be considered as tumor regression at sites are outside the irradiated volume, this phenomenon was called abscopal antitumor effect. The article presents results model study very aggressive ascitic mammary “Ehrlich ascites carcinoma” (EAC) used for study. First, one-step bilateral grafting EAC cells to mice hind extremities performed, following step formation contralateral nodes in hips. In 5 days after transplantation, right (target) node locally with 60Co gamma rays dose 30 Gy. growth left (non-target) and target watched during 20 irradiation. It found local irradiation Gy an early stage caused inhibition left, non-target from 10 49% relative control group bearing mice. order reduce burden model, impact fractionated single Gy, total studied. ability immune system transplanted tumors both hips respond antigenic stimulus following: mice, transected thighs subsequent gamma-ray stimulus; radiation doses crucial achieving effect; use complementary therapeutic methods, such targeted or immunotherapy, will increase probability achieving.